Isoniazid Preventive Therapy (IPT) is a proven intervention for preventing the development of active tuberculosis
(TB) in people living with HIV (PLHIV). However, despite its effectiveness, the uptake of IPT among PLHIV
remains low, especially in resource-limited settings such as Ntungamo district in Uganda. To determine the
knowledge, attitude, and practices towards the use of isoniazid preventive therapy (IPT) among HIV-positive
patients at Itojo Hospital, Ntungamo District. This descriptive cross-sectional study aimed to assess the
knowledge, attitudes, and practices of IPT among HIV-positive patients attending Itojo Hospital in Ntungamo
district. We recruited a total of 50 participants using simple random sampling, and collected data using a
structured questionnaire. We used descriptive statistics and logistic regression to analyze the data and determine
the likelihood of the outcomes. The study involved 50 participants who volunteered. It was depicted that female
gender (p-value: 0.016, aOR: 2.59 (0.63–10.71)), age of 31–35 years (p-value: 0.016, aOR: 0.17 (0.02-1.51) and
tertiary level of education (p-value: 0.025, aOR: 1.76 (0.31–9.46)) were significant predictors of knowledge.
Primary level education (p-value: 0.02, aOR: 1.28(0.34-4.85)) and unemployment (p-value: 0.05, aOR: 0.22(0.05-
1.01)) were significantly associated with attitudes towards the use of IPT among HIV-positive patients at Itojo
Hospital. Age of 26–30 years (p-value: 0.003, aOR: 4.427(0.068–288.290)) and secondary level of education (pvalue:
0.046, aOR: 1.23(0.961–1.565)) were significantly associated with the practices towards the use of IPT
intake. The study identified age, gender, and level of education as significant predictors of knowledge, attitude, and
practices towards the use of IPT intake among HIV-positive patients at Itojo Hospital. The findings indicate the
need for improved education and awareness campaigns on IPT intake among PLHIV in Ntungamo district.
Addressing concerns related to side effects and improving access to health facilities could also increase the uptake
of IPT. These findings can inform the development of targeted interventions to improve the uptake of IPT among
PLHIV in resource-limited settings