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Title: | Unveiling the Role of GATA-1 in Hematopoietic Stem Cell Function in HIV: Therapeutic Implications |
Author(s): | *Emmanuel Ifeanyi Obeagu1 and Getrude Uzoma Obeagu2 |
Year | 2024 |
Publisher: | International Journal of Current Research in Medical Sciences |
URI: | https://publications.kiu.ac.ug/publication-page.php?i=unveiling-the-role-of-gata-1-in-hematopoietic-stem-cell-function-in-hiv-therapeutic-implications |
File: | |
Keywords: |
Hematopoietic stem cell (HSC) dysfunction is a significant contributor to immune impairment in HIV infection.
GATA-1, a pivotal transcription factor in hematopoiesis, emerges as a key regulator influencing HSC function and
lineage commitment. This review explores the intricate relationship between GATA-1 and HSCs in the context of
HIV, shedding light on potential therapeutic implications. We discuss the impact of GATA-1 dysregulation on
hematopoietic processes in HIV, highlighting its role in immune cell differentiation and activation. Furthermore, we
examine therapeutic strategies targeting GATA-1 to restore normal hematopoiesis and enhance immune reconstitution
in HIV-infected individuals. This comprehensive analysis underscores the importance of understanding GATA-1-
mediated mechanisms in shaping immune responses during HIV infection and emphasizes the therapeutic potential of
targeting GATA-1 for mitigating immune dysfunction and improving patient outcomes.
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