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Title: | Aqueous Extracts of Vernonia Amygdalina and Ocimum Gratissimum Protect Against Electrolyte Derangement in Salt-Loaded Rats |
Author(s): | Ugochukwu Vincent Igbokwe, Ejike Daniel Eze, Moses Dele Adams and Chidimma Felicia Chukwuegbo |
Year | 2020 |
Publisher: | International Journal of Pharmaceutical Sciences and Research 11(4) |
URI: | https://publications.kiu.ac.ug/publication-page.php?i=aqueous-extracts-of-vernonia-amygdalina-and-ocimum-gratissimum-protect-against-electrolyte-derangement-in-salt-loaded-rats |
File: | |
Keywords: | Vernonia amygdalina Ocimum gratissimum Asteraceae Labiatae Electrolyte Salt-induced hypertension |
The study aimed at checking the effects of aqueous extracts of
Vernonia amygdalina and Ocimum gratissimum on the electrolyte level of saltloaded rats. 25 male rats weighing 160-220g were shared into 5 groups of 5 rats.
Group 1 animals that were fed standard feed and water served as the control.
Animals in group 2-5 which were salt-loaded orally with 2 ml of 4% sodium
chloride solution for 2 weeks, were left untreated, treated with 1 ml of 300 mg/kg
body weight of aqueous bitter leaf extract, 300 mg/kg body weight of aqueous
extract of scent leaf and 300 mg/kg body weight of both extracts in ratio 1:1
respectively. Treatment of salt-loaded animals with the extract was done orally once
daily for two weeks after which plasma electrolyte levels were determined. There
was significant (P<0.05) increase in Na+
and Cl− levels in all the salt-loaded groups
when compared with the control group. Bitter leaf extracts significantly (P<0.05)
decreased the sodium level only when compared to the group with no treatment
while scent leaf extract did not affect (P>0.05) on any of the electrolytes. Treatment
with both extracts reduced Na+ and Cl− levels significantly (P<0.05). Individual and
co-treatment with bitter leaf and scent had no change (P>0.05) in the levels of K+ and
HCO3
−
. The co-administration of aqueous extract of Vernonia amygdalina and
Ocimum gratissimum has synergistic effect that might be of importance in reduction
of blood electrolytes of sodium and chloride in salt-induced derangements. This
might be useful in managing salt-induced hypertension.
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