KIU Publications

Research outputs, reports, policy briefs and knowledge products from KIU scholars and partners.

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2026 Faculty of Biomedical Sciences

Theranostic Nanoparticles in Prostate Cancer: Disrupting Hypoxia- Induced Glycolysis by Targeting Hypoxia- Inducible Factor- 1 Alpha and Downstream Metabolites

Daniel Ejim Uti, Wilson Achu Omang, Esther Ugo Alum, Inalegwu Bawa, Okechukwu Paul-Chima Ugwu, Ayodeji Oluwafemi Idowu, Item Justin Atangwho, Godwin Eneji Egbung

2026 | Cancer Medicine | Pp. 1-25

Background: Prostate cancer (PCa) is a major cause of cancer- associated death in men. A crucial factor in its development and treatment resistance is tumor hypoxia, which drives metabolic reprogramming (especially reconfiguration towards glycolysis), mediate...

2026 Faculty of Biomedical Sciences

Targeting CD44-Hyaluronic Acid Signalling in Obesity Treatment: Insights from Small Molecules and Nanobioconjugates

Daniel Ejim Uti, Wilson Achu Omang, Esther Ugo Alum, Okechukwu Paul-Chima Ugwu, Margaret Amieibi Wokoma, Rowland Inalegwu Oplekwu, Item Justin Atangwho and Godwin Eneji Egbung

2026 | Nutrition and Metabolic Insights | Pp. 1-29

Obesity is a complex metabolic disorder associated with chronic low-grade inflammation, insulin resistance, and heightened risk of comorbidities such as cardiovascular diseases and type 2 diabetes mellitus (T2DM). The Cluster of Differentiation 44 (CD44), a t...

2026 Faculty of Biomedical Sciences

Recent Advances in Plant- Based Dairy Alternatives: Technological Innovations, Nutritional Enhancement, Sustainability, and Consumer Perspectives

Nabeel Ashraf, Zunaira Arshad, Ahmad Din, Huma Bader Ul Ain, Esther Ugo Alum, Tabussam Tufail

2026 | Wiley | Pp. 1-24

Plant- based beverages (PBBs) have attracted considerable attention from the global dairy industry as a viable substitute to the milk industry due to their sustainability, nutritional value, and economics. An emerging trend is PBBs, which can be an affordable...

2026 Faculty of Biomedical Sciences

Plant- and soil-derived polyphenols shape soil microbiomes and crop outcomes: a systematic review and meta-analysis

Ugwu OP-C, Ogenyi FC, Alum EU, Basajja M, Ugwu JN, Ugwu CN, Ejemot-Nwadiaro RI, Okon MB, Ejim UD, Mustafa MM, Muhammad A and Reshia FAA

2026 | Frontiers in Soil Science | Pp. 1-11

Background: Polyphenols from root exudates and polyphenol-rich organicinputs may shape soil microbiomes, enzyme activities, and crop nutrientoutcomes, with relevance to regenerative agriculture.Objectives: To quantify the effects of plant- and soil-derived po...

2026 Faculty of Biomedical Sciences

Overcoming the Black Box Challenge: Building Trust in Artificial Intelligence Algorithms in Oncology

Esther Ugo Alum, Chukwuoyims Kevin Egwu, Vaithiyalingam Subramanian Manjula, Patience Owere Ekpang, Joseph Enyia Ekpang II, Darlington Arinze Echegu, Benedict Nnachi Alum, and Daniel Ejim Uti

2026 | Technology in Cancer Research & Treatment | Pp. 1-21

Rising global cancer rates are projected to significantly increase by 2050, highlighting the urgent need for improved scalable prevention, early detection, and personalized therapy tools. Artificial intelligence (AI) has demonstrated significant capabilities...

2026 Faculty of Biomedical Sciences

Next-generation strategies against prostate cancer: natural products and nanomedicine targeting prostate cancer stem cells

Daniel Ejim Uti, Wilson Achu Omang, Esther Ugo Alum, Inalegwu Bawa, Okechukwu Paul-Chima Ugwu, Simeon Ikechukwu Egba

2026 | Journal of Men's Health | Pp. 1-21

Recurrence, metastasis, and treatment resistance are significant issues in prostate cancermanagement. Evidence increasingly substantiates the notion that prostate cancer stemcells (PCSCs) initiate cancer, facilitate its progression, and complicate therapy. Th...

2026 Faculty of Biomedical Sciences

Maternal Nutrition, Toxicants, and Epigenetic Programming of Obesity Across Generations

Esther Ugo Alum, Henry Egi Aloh, David Chukwu Obasi, Prince Nkemakolam Okoroh, Ugonna Cassandra Aniokete & Akunna Perpetua Emeruwa

2026 | Diabetes, Metabolic Syndrome and Obesity | Pp. 1-40

Background: The developmental origins of health and disease (DOHaD) framework highlights the importance of the intrauterine environment in shaping lifelong health outcomes. Maternal nutrition, toxic exposures, and epigenetic reprogramming are key factors infl...

2026 Faculty of Biomedical Sciences

Investigating the role of perceived organisational support in the relationship between human resource skill adjustment and corporate sustainability in the hospitality industry

Friday Ogbu Edeh, Desmond Oben Neji, Collins Okechukwu Irem, Esther Ugo Alum, Vitalii S. Nitsenko, Gladys Onah Owere, Agnes Ugboego Chukwu, Kingsley Sunday Uzoadigonma Oyekezie, Chichi Maureen Anyalor, and Mary Aluoch Odenyo

2026 | Discover Sustainability | Pp. 1-22

Human resource skill adjustment is a process of upgrading workforce skills to match current realities in the organisation. The essence of upgrading employees’ skills is to enhance the sustainability of the organisation. Based on the contingency theory of soci...

2026 Faculty of Biomedical Sciences

Invasive species as threat multipliers in freshwater ecosystems: biodiversity loss, interacting stressors, and management responses in the Anthropocene

Izah SC, Ogwu MC, Promise VI, Alum EU, Poyeri WR, Kari A and Raimi MO

2026 | Frontiers in Ecology and Evolution | Pp. 1-19

Freshwater ecosystems occupy a small proportion of the Earth’s surface yetsupport exceptionally high biodiversity and essential ecosystem services. In theAnthropocene, these systems are increasingly threatened by interacting pressures, including hydrological...

2026 Faculty of Biomedical Sciences

Immunomodulatory Effects of Zinc and Selenium- Enriched Lentinula edodes Extract: Biochemical Characterization and Bioactivity Relevant to Tuberculosis

Hanif Mughal, Tabussam Tufail, Huma Bader ul Ain, Amara Rasheed, Esther Ugo Alum

2026 | Wiley | Pp. 1-14

The primary hypothesis of the study was that zinc and selenium supplementation through fortified cookies would enhance the immune response and improve clinical outcomes in tuberculosis patients. For this purpose, a single- blind randomized control trial was c...