Research outputs, reports, policy briefs and knowledge products from KIU scholars and partners.
Scholarly Work
Search peer-reviewed articles, reports, books, policy briefs and other scholarly outputs by KIU researchers and collaborators.
2024 | Elite Journal of Immunology. | Pp. 45-61
HIV infection during early life poses unique challenges to neonatal immune development, potentially leading to immune exhaustion and increased susceptibility to infections. This review explores the mechanisms and implications of HIV-induced immune exhaustion...
2024 | Elite Journal of HIV | Pp. 35-53
The programmed cell death protein 1 (PD-1) pathway plays a pivotal role in immune regulation and tolerance. In the context of HIV/AIDS, dysregulation of the PD-1 pathway contributes to T-cell exhaustion, immune dysfunction, and disease progression. This revie...
2024 | Elite Journal of Health Sciences | Pp. 24-40
Hematopoietic stem cells (HSCs) are pivotal for maintaining blood cell production and immune function, and their dysregulation is implicated in hematological abnormalities observed in Human Immunodeficiency Virus (HIV) infection. GATA-1, a master transcriptio...
2024 | Elite Journal of Immunology
CD8 T cells are key players in the immune response against HIV, tasked with identifying and eliminating virus-infected cells. However, the battle between HIV and CD8 T cells is complex, marked by a dynamic interplay between viral evasion strategies and host i...
2024 | Elite Journal of Immunology | Pp. 18-35
Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is a critical immune checkpoint molecule involved in regulating T cell activation and tolerance. Genetic variations in CTLA-4 have been implicated in modulating susceptibility to human immunodeficiency viru...
2024 | Elite Journal of Health Sciences | Pp. 7-23
GATA-1 mutations have been implicated in various hematological disorders, and emerging evidence suggests their association with HIV infection, leading to a spectrum of hematological abnormalities. This review explores the role of GATA-1 mutations in HIV-assoc...
2024 | Elite Journal of Scientific Research and Review | Pp. 20-36
GATA-1, a key transcription factor, plays a crucial role in regulating megakaryocyte function and platelet production. In the context of HIV infection, dysregulation of GATA-1 signaling pathways contributes to hematologic abnormalities, including thrombocytop...
2024 | Elite Journal of Immunology | Pp. 1-17
HIV infection is associated with an increased risk of lymphomas, presenting a therapeutic challenge due to the complex interplay between immune dysfunction and tumorigenesis. The programmed cell death protein 1 (PD-1) pathway has emerged as a pivotal immune c...
2024 | Elite Journal of HIV | Pp. 1-17
Immune dysregulation is a hallmark feature of HIV/AIDS, contributing significantly to disease progression and complications. Despite advancements in antiretroviral therapy (ART), immune dysfunction persists in HIV/AIDS patients, necessitating a deeper underst...
2024 | Elite Journal of Scientific Research and Review | Pp. 1-19
Antacid use is prevalent among HIV patients due to gastrointestinal symptoms and the side effects of antiretroviral therapy (ART). This review examines the implications of antacid use in HIV patients, focusing on drug absorption, metabolism, and adverse effec...