KIU Publications

Research outputs, reports, policy briefs and knowledge products from KIU scholars and partners.

Scholarly Work

KIU publications archive

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2026 School of Natural and Applied Sciences

Nanotechnology-Driven Modulation of Adipose Tissue Browning: Therapeutic Implications for Obesity Associated Type 2 Diabetes

Wambui Kibibi J.

2026 | NEWPORT INTERNATIONAL JOURNAL OF RESEARCH IN MEDICAL SCIENCES (NIJRMS) | Pp. 87-94

Obesity-associated type 2 diabetes (T2D) arises from chronic positive energy balance, adipose tissue dysfunction, low-grade inflammation, and insulin resistance. Converting energy-storing white adipose tissue into thermogenically active beige/brown–like adipo...

2026 School of Natural and Applied Sciences

Nanotechnology-Based Delivery Systems for Anti Obesity and Antidiabetic Phytochemicals

Wambui Kibibi J.

2026 | NEWPORT INTERNATIONAL JOURNAL OF RESEARCH IN MEDICAL SCIENCES (NIJRMS) | Pp. 95-101

Phytochemicals have long served as bioactive agents against metabolic disorders such as obesity and type 2 diabetes mellitus (T2DM). However, their poor solubility, instability, rapid metabolism, and low bioavailability hinder clinical efficacy. Nanotechnolog...

2026 School of Natural and Applied Sciences

Nanotechnology in the Management of Obesity and Diabetes: A Convergent Frontier in Metabolic Disease Therapy

Maina Mwaura F.

2026 | NEWPORT INTERNATIONAL JOURNAL OF RESEARCH IN MEDICAL SCIENCES (NIJRMS) | Pp. 81-86

Obesity and diabetes mellitus (DM) are interrelated global health crises, jointly termed diabesity, that arise from complex metabolic, genetic, and behavioral factors. Both conditions promote insulin resistance, oxidative stress, and systemic inflammation, pr...

2026 School of Natural and Applied Sciences

Nanotechnology in Appetite Regulation: Targeting Hypothalamic Pathways and Gut-Brain Axis in Obesity

Mwende Wairimu G.

2026 | NEWPORT INTERNATIONAL JOURNAL OF RESEARCH IN MEDICAL SCIENCES (NIJRMS) | Pp. 73-80

Obesity is increasingly understood as a brain-centric disorder in which hypothalamic circuits and the gut–brain axis fail to correctly integrate peripheral signals of energy status. Hypercaloric diets and adipose expansion drive leptin and insulin resistance,...

2026 School of Natural and Applied Sciences

Nanotechnology Enhanced Photothermal and Photodynamic Therapies in Obesity-Associated Cancers

Mwende Wairimu G.

2026 | NEWPORT INTERNATIONAL JOURNAL OF RESEARCH IN MEDICAL SCIENCES (NIJRMS) | Pp. 67-72

Obesity imposes optical, vascular, metabolic, and pharmacokinetic constraints that blunt the performance of photothermal therapy and photodynamic therapy while exacerbating off-target toxicity. Enlarged adipose depots scatter and absorb light differently from...

2026 Faculty of Science and Technology

Nanotechnology Approaches in Enhancing Bioavailability of Plant Derived Antidiabetic Compounds for Obesity-Linked Diabetes

Kibibi Muthoni L.

2026 | NEWPORT INTERNATIONAL JOURNAL OF RESEARCH IN MEDICAL SCIENCES (NIJRMS) | Pp. 1-11

Obesity-linked type 2 diabetes (T2D) arises from chronic nutrient excess, ectopic lipid deposition, and unresolved inflammation that together blunt insulin signaling and exhaust β-cell function. Plant-derived antidiabetic compounds, flavonoids (quercetin, kae...

2026 Faculty of Clinical Medicine and Dentistry

Nanosensors for Early Detection of Obesity-Related Metabolic Disorders

Nyiramana Mukamurera P.

2026 | NEWPORT INTERNATIONAL JOURNAL OF RESEARCH IN MEDICAL SCIENCES (NIJRMS) | Pp. 48-52

Obesity is strongly linked to metabolic disorders such as type 2 diabetes, dyslipidemia, cardiovascular disease, and non-alcoholic fatty liver disease. Early detection of these complications is crucial for timely intervention, yet current diagnostic methods o...

2026 Faculty of Clinical Medicine and Dentistry

Nanoparticle-Mediated Gut Microbiota Modulation in Obesity: Mechanistic Insights and Therapeutic Prospects

Nyiramana Mukamurera P.

2026 | NEWPORT INTERNATIONAL JOURNAL OF RESEARCH IN MEDICAL SCIENCES (NIJRMS) | Pp. 39-47

Obesity is a chronic, relapsing metabolic disease in which the gut microbiota plays a central regulatory role. Dysbiosis, impaired barrier integrity and altered microbial metabolites contribute to increased energy harvest, low-grade inflammation, insulin resi...

2026 Faculty of Clinical Medicine and Dentistry

Nanoparticle-Induced Modulation of Inflammatory Pathways in Obesity: From Mechanistic Understanding to Therapeutic Design

Nyiramana Mukamurera P.

2026 | NEWPORT INTERNATIONAL JOURNAL OF RESEARCH IN MEDICAL SCIENCES (NIJRMS) | Pp. 31-38

Obesity is characterized by chronic low-grade inflammation that originates primarily in expanding white adipose tissue and propagates to liver, skeletal muscle, vascular endothelium and pancreas, driving insulin resistance and cardiometabolic complications. H...

2026 Faculty of Science and Technology

Nanoparticle-Encapsulated Artemisinin Derivatives for Plasmodium falciparum: Comparative Efficacy, Pharmacokinetics, and Resistance Prevention

Kato Jumba K.

2026 | NEWPORT INTERNATIONAL JOURNAL OF PUBLIC HEALTH AND PHARMACY (NIJPP) | Pp. 95-100

Malaria remained a critical global health challenge, with Plasmodium falciparum causing approximately 229 million cases and 409,000 deaths annually, predominantly affecting sub-Saharan Africa. Traditional artemisinin-based combination therapies face mounting...