Publications

Title: A narrative review on the basic and clinical aspects of the novel SARS-CoV-2, the etiologic agent of COVID-19
Author(s): Joseph Hokello, Adhikarimayum Lakhikumar Sharma, Girish C. Shukla, Mudit Tyagi
Year 2020
Publisher: Annals of Translational Medicine.
URI: https://publications.kiu.ac.ug/publication-page.php?i=a-narrative-review-on-the-basic-and-clinical-aspects-of-the-novel-sars-cov-2-the-etiologic-agent-of-covid-19
File: PDF
Keywords: Replication Transmission Pathogenesis SARS-CoV-2 coronavirus disease 19 (COVID-19)

The novel SARS-CoV-2 is responsible for causing the ongoing outbreak of coronavirus disease
19 (COVID-19), a systemic infection in humans. Ever since it was first detected in December 2019, the
number of confirmed cases has continued to increase. Within a short period, this disease has become a
global issue, and therefore it is characterized as a pandemic. The current understanding and explanations
are based on epidemiological, clinical and physiological observations. Besides, it remains a great challenge,
as much remains to be understood about this new disease-causing virus. Therefore, we seek to provide
an overview of SARS-CoV-2, including its classification, origin, genomic structure, replication cycle,
transmission, pathogenesis, clinical aspects, diagnosis, treatments, prevention and vaccine options. We
conducted a literature search for the articles published up to August 2020 using the keywords ‘SARCoV-
2’ and ‘COVID19’ in medical databases; PubMed, google scholar, EMBASE, and web of science.
Based on the information collected, the emerging COVID-19, caused by SARS-CoV-2, exhibits strong
infectivity but less virulence in terms of severity of disease and mortality rates in certain age groups. It
inflicts more damage in terms of peoples’ health and well-being, social life, and global economic impacts.
Unfortunately, there is no adequate global and standard response to this pandemic to date, and each
country is facing a crisis based on its situation, expertise, and hypotheses. While there is no effective
therapy and vaccine against the novel SARS-CoV-2 yet, preventive measures are the only tool available to
our disposal to control the spread of the COVID-19 pandemic. Ongoing and future research is focused
more on developing standard treatment strategies, and efficacious vaccines, which would be useful to
tackle this pandemic globally.


KIU

Our Contacts

Kampala International University,
Box 20000, Ggaba Road, Kansanga, Kampala

+(256) 392 001 816
+(256) 752 800 802