Malaria remains a significant global health threat, causing hundreds of thousands of deaths annually. Understanding
the host's protective mechanisms against this parasitic infection is crucial for developing effective prevention and
treatment strategies. Hepcidin, a central regulator of iron homeostasis, has emerged as a key player in the host's
defense against malaria. This comprehensive review explores the multifaceted roles of hepcidin in safeguarding the
host from malaria infection. We delve into the molecular mechanisms of hepcidin regulation and its impact on the
intricate interplay between iron, the immune system, and Plasmodium species. Additionally, we discuss the potential
therapeutic implications of targeting hepcidin to enhance antimalarial responses. By shedding light on hepcidin's
antimalarial arsenal, this review aims to contribute to the development of innovative strategies for combating
malaria.