The intricate interplay between the liver, kidney, and heart in metabolic regulation and cardioprotection
is a topic of growing interest, particularly in the context of rising cardiovascular disease prevalence. This
paper explores the dynamic interactions among these organs, highlighting their roles in energy
metabolism, inflammation, and cardiovascular health. We discuss the mechanisms through which liver
and kidney function impact cardioprotective properties, including the regulation of glucose and lipid
metabolism, inflammation modulation, and remote conditioning effects. Furthermore, we examine the
implications of liver-kidney-heart cross-talk for therapeutic strategies targeting cardiometabolic
disorders. Understanding these complex interactions is essential for the development of innovative
treatments to mitigate the burden of cardiovascular disease