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Title: | L-selectin in Tuberculosis-HIV Coinfection: Linking Immune Activation to Disease Outcome |
Author(s): | Emmanuel Ifeanyi Obeagu1 and Emmanuel Chinedu Onuoha2 |
Year | 2024 |
Publisher: | Elite Journal of Health Sciences |
URI: | https://publications.kiu.ac.ug/publication-page.php?i=l-selectin-in-tuberculosis-hiv-coinfection-linking-immune-activation-to-disease-outcome |
File: | |
Keywords: |
Tuberculosis (TB) and Human Immunodeficiency Virus (HIV) coinfection present a significant challenge to global health, with complex interactions between these pathogens influencing disease outcomes and treatment responses. L-selectin, a key mediator of leukocyte trafficking and immune activation, has emerged as a crucial molecule in the pathogenesis of TB-HIV coinfection. This review aims to elucidate the role of L-selectin in TB-HIV coinfection, focusing on its implications for immune activation and disease outcome. We discuss the intricate interplay between TB and HIV in modulating L-selectin expression and function, as well as its impact on immune responses, disease severity, and treatment outcomes. Furthermore, we explore the potential of targeting L-selectin-mediated immune pathways as a therapeutic strategy for improving disease control and patient prognosis in TB-HIV coinfection.
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