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An Insight of Interleukin -6 and Fibrinogen: In Regulating the Immune System
Author: Emmanuel Ifeanyi Obeagu1*, Emmanuel Muhimbura2, Byamungu Pahari Kagenderezo3, Sarah Nakyeyune4 and Getrude Uzoma Obeagu1
Publisher: Journal of Biomedical Sciences
Published: 2022
Section: School of Allied Health Sciences
Abstract
The role of the liver as a critical part of the immune system involved in both innate
and adaptive immunity. As a major source of acute phase proteins, including
components of the complement system. Hepatocytes are an important part of
innate immunity and play an important role in controlling inflammatory responses
throughout the body. Acute-phase protein production in hepatocytes is controlled
by various cytokines released during the inflammatory process, with IL-6 and IL-1
type cytokines acting as key regulators, cascading and synergistic regulation or
it functions as a cascade network with inhibition. Effects on acute-phase protein
expression. The pro inflammatory cytokine interleukin-6 is an endogenous
biochemical active during B cell maturation and inflammatory processes.
Interleukin-6 plays an important role in regulating acute-phase protein synthesis
in human hepatocytes.