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Postprandial Hypolidaemic Effect of Aloe Vera Methanolic Extract via the Mechanism of Intestinal Pancreatic Lipase Enzyme Inhibition in Male Wistar Rats
Author: 1Faseun Yusuf Olusola, 2*Ezeonwumelu Joseph Obiezu Chukwujekwu, 3Odda John, 3Odoma Saidi, 4Idania Hidalgo, 5Moazzam Mohiuddin Lodhi, 6Patrick Maduabuchi Aja, 7Hambali Kaltume Umar, 6Mpumbya Jackie Rachael, 2Ebere Emilia Ayogu, 2Narayana Goruntla, 3Hope Onohuean and 8Ugwu Okechukwu Paul-Chima
Publisher: IDOSR JOURNAL OF BIOLOGY, CHEMISTRY AND PHARMACY
Published: 2023
Section: School of Pharmacy
Abstract
This study explores the ability of Aloe vera, a traditional medicinal plant, to inhibit the
digestive enzyme pancreatic lipase and its potential impact on post-prandial lipidaemia in
adult male Wistar rats. Aloe vera extract was administered in varying doses alongside olive
oil as a source of triglycerides. The study investigates the kinetics of post-prandial blood
triglyceride concentration, Area Under the Curve (AUC) values, and the percentage inhibition
of pancreatic lipase. The results reveal significant inhibition of pancreatic lipase, indicating
a potential role in moderating post-prandial blood lipid levels. The inhibition type is suggested to be a mixed type, combining uncompetitive and competitive characteristics. This
finding suggests that Aloe vera may have therapeutic potential in managing conditions
related to post-prandial dyslipidaemia, such as diabetes.