Abstract

Hemolysis in pregnancy represents a complex and multifaceted challenge, particularly for individuals grappling with sickle
cell anemia. This review delves into the intricate interplay between the physiological changes induced by pregnancy and
the underlying pathophysiology of sickle cell anemia. It provides a comprehensive examination of the clinical implications,
management strategies, and recent research advances pertaining to hemolysis in pregnant women with sickle cell anemia.
The physiological adaptations inherent in pregnancy, including alterations in the cardiovascular and hematologic systems,
create a dynamic environment that may exacerbate hemolysis in individuals with sickle cell anemia. This review elucidates
the intricacies of these changes, establishing a foundation for understanding the heightened risks and challenges faced by
pregnant women with this inherited blood disorder. Effective management strategies are crucial for optimizing outcomes
in pregnant women with sickle cell anemia experiencing hemolysis. This review provides an in-depth analysis of various
approaches, including the role of hydroxyurea therapy, blood transfusions, and meticulous monitoring of maternal and fetal
parameters. By evaluating the potential benefits and risks of each strategy, clinicians are equipped with valuable insights to
tailor interventions to individual patient needs. In conclusion, this comprehensive review offers a synthesized perspective
on the considerations surrounding hemolysis in pregnancy for individuals with sickle cell anemia. Bridging the realms of
physiology, clinical practice, and research, it provides a valuable resource for healthcare professionals, researchers, and
policymakers seeking to enhance the care and outcomes of pregnant women grappling with sickle cell anemia and heightened
hemolytic challenges.