Abstract

Sickle cell anemia (SCA) is a hereditary blood disorder characterized by abnormal hemoglobin, causing red blood cells to assume
a sickle shape, leading to various complications. Climate change has emerged as a significant global challenge, influencing
environmental conditions worldwide. This paper explores the implications of climatic variations on the prevalence, management,
and outcomes of SCA. Climate change affects weather patterns, leading to altered temperatures, increased frequency of extreme
weather events, and variations in humidity levels. These changes can have a profound impact on individuals living with SCA.
High temperatures exacerbate the symptoms of SCA, potentially triggering painful vaso-occlusive crises due to dehydration
and increased blood viscosity. Conversely, cold temperatures may induce vaso-occlusion by causing blood vessels to constrict.
Changes in rainfall patterns might also affect water accessibility, which is crucial for maintaining adequate hydration, particularly
in regions prone to droughts. The management of SCA is multifaceted, involving regular medical care, hydration, and avoiding
triggers that could precipitate a crisis. Adverse weather events and natural disasters can disrupt healthcare infrastructure and
access to essential medications and resources for SCA patients, especially in vulnerable communities. To mitigate the implications
of climatic change on SCA, interdisciplinary strategies are essential. These strategies may include enhancing healthcare systems’
resilience to climate-related disruptions, implementing adaptive measures to address changing environmental conditions, and
promoting public awareness and education on managing SCA amidst climate variability. In conclusion, climatic variations pose
significant challenges for individuals with SCA, affecting the prevalence, management, and outcomes of the disease.