Abstract

In the realm of global health diplomacy, diabetes mellitus undoubtedly poses a significant challenge. Furthermore,
there is a pressing need to explore alternative and complementary therapies. Phytochemicals, which are naturally
occurring bioactive compounds found in plants, exhibit distinct biochemical properties, rendering them promising
candidates for diabetes management. This review focuses on the potential of various classes of phytochemicals,
including polyphenols, alkaloids, terpenoids, organosulfur compounds, and polysaccharides, in diabetes
management. Each class demonstrates unique mechanisms of action, contributing to therapeutic effects such as
enhancing insulin sensitivity, reducing carbohydrate digestion and glucose absorption, regulating antioxidant
stress, inflammation, and glucose metabolism. While successful preclinical trials provide valuable insights, further
rigorous clinical trials are imperative to ascertain the therapeutic efficacy, optimal dosage, bioavailability, and
potential interactions with concomitant medications. Understanding the functional pathways of plant-derived
substances is crucial, as it enables the formulation of precise strategies for incorporating them as dietary supplements
for individuals with diabetes mellitus.
Keywords: Phytochemicals, diabetes mellitus, insulin sensitivity, glucose metabolism, oxidative stress, and
inflammation