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Serum Bilirubin Levels in Patients with Acute Appendicitis in Western Uganda: A Multicenter Study
Author: Cikuru Rodrigue Buhendwa1, Edyedu Isaac1, Idania Hidalgo2, Simba Lionel Msafiri1, Olivier Iyivuze1, Kumbakulu Patrick Kumbowi3, Maxwel Duncan Okuku1, Khodolwa Stephen Angira1, M’mebwa Mtende Luc4 and Emmanuel Ifeanyi Obeagu5
Publisher: Elite Journal of Medicine
Published: 2024
Section: School of Allied Health Sciences
Abstract
Globally, acute appendicitis, requiring emergency surgery, occurs in 7 to 22 cases per 10,000 persons. The study aimed to assess the correlation between acute appendicitis and serum bilirubin. This was observational prospective cohort study, conducted in Western Uganda from November 2023 to January 2024, involved 62 adult patients diagnosed with acute appendicitis. Eligibility was determined by an Alvarado score exceeding 7. Serum levels of bilirubin were measured, with hyperbilirubinemia defined as >1.1 mg/dl for total bilirubin. Intraoperative severity of appendicitis was compared with biomarker levels. Hyperbilirubinemia was evident in 35.5% (95% CI: 23.7-48.7%). Elevated serum procalcitonin and bilirubin are observed in patients with acute appendicitis. The presence of heightened bilirubin levels is significantly associated with complicated appendicitis