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The Crucial Involvement of CD8 in HIV Progression: A Review
Author: Emmanuel Ifeanyi Obeagu1 and Getrude Uzoma Obeagu2
Publisher: International Journal of Current Research in Medical Sciences
Published: 2024
Section: School of Allied Health Sciences
Abstract
The relentless global impact of Human Immunodeficiency Virus (HIV) underscores the urgency of understanding the
intricate immune responses involved in its progression. CD8 T cells play a central role in orchestrating the immune
defense against HIV, wielding the potential to both curtail viral replication and, paradoxically, succumb to
exhaustion. This comprehensive review explores the multifaceted engagement of CD8 T cells in HIV pathogenesis. It
encompasses the mechanisms underlying CD8 T cell recognition, the protective effects they exert, factors influencing
their efficacy, and the emerging landscape of CD8-focused therapeutic interventions. Delving into the delicate
balance between immune defense and viral evasion, this review seeks to provide a nuanced understanding of CD8 T
cell involvement in HIV progression and illuminate the prospects for future therapeutic advancements.
Keywords: HIV,