Abstract

The research aimed at evaluating the safety or toxicity outcomes of ciprofloxacin and gentamicin co-administration and the possible ameliorating role of vitamin C and E. Wistar albino rats were divided into five groups of five rats in each group. Animals were co-administered ciprofloxacin (7.14 mg/kg) and gentamicin (1.14 mg/kg) and treated with vitamin C (100 mg/kg), vitamin E (1000 iu) or a co-administration of vitamin C and E at the initial dose. After 11 days, various hematological, biochemical and histological studies were performed. The result showed that co-administration of ciprofloxacin and gentamicin significantly reduced hemoglobin concentration, packed cell volume, red blood cell count, alkaline phosphatase, total protein, albumin, cholesterol, superoxide dismutase and catalase. Increased blood level in total white blood cell count, serum urea, creatinine, total bilirubin, glutathione, malondialdehyde, C-reactive protein and creatine kinase were observed after ciprofloxacin and gentamicin co-administration. The co-administration of antioxidants vitamins (C and E) maintained plasma/serum hematological, biochemical and antioxidant status similar to control. Histological observation of the kidney and liver sections substantiated the biochemical findings