Abstract

Human immunodeficiency virus (HIV) infection remains a significant global health concern, necessitating ongoing research
and innovation in the quest for improved disease management. Traditional markers for monitoring HIV progression and the
effectiveness of antiretroviral therapy have limitations in capturing the intricate immune responses and inflammatory dynamics in
people with HIV. In recent years, the concept of inflammation ratios has gained prominence as a valuable tool for assessing and
understanding the complex interplay between inflammation, immune function, and HIV. In this abstract, we provide an overview of
the emerging field of utilizing inflammation ratios in the context of HIV and its implications for disease monitoring and therapeutic
strategies. These ratios, such as the CD4/CD8 ratio, neutrophil-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio, offer a
more comprehensive assessment of an individual’s immune status and inflammatory state. By exploring the clinical implications
of inflammation ratios, including their potential to predict disease complications and guide personalized treatment approaches,
this publication sheds light on the potential benefits of incorporating inflammation ratios into routine HIV care. Furthermore, we
emphasize the importance of ongoing research in this field to further refine our understanding of the utility and significance of
inflammation ratios in improving the lives of people with HIV.
Abbreviations: AIDS = acquired immunodeficiency syndrome, ART = antiretroviral therapy, CD4 = clusters of differentiation
4, CD8 = clusters of differentiation 8, HIV = human immunodeficiency virus, INRs = immunological non-responders, MLR =
monocyte-to-lymphocyte ratio, NLR = neutrophil-to-lymphocyte ratio, PWH = people with HIV.
Keywords: CD4/CD8 ratio, HIV, inflammation ratios, MLR, monitoring, NLR, therapeutic strategies