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Balancing Act: Deciphering the Significance of CD4/CD8 Ratios in HIV Immunology
Author: Emmanuel Ifeanyi Obeagu1, Chioma Ibe2, Getrude Uzoma Obeagu3, Chinyere Nkemjika Anyanwu4 and Ebere Emilia Ayogu5,6
Publisher: International Journal of Innovative and Applied Research
Published: 2024
Section: School of Allied Health Sciences
Abstract
The management of Human Immunodeficiency Virus (HIV) necessitates a nuanced comprehension of immune responses, with the CD4/CD8 ratio emerging as a pivotal parameter in this regard. This review investigates the clinical implications of CD4/CD8 ratios in HIV, encompassing their role as prognostic markers, treatment monitoring tools, and indicators of immunological reconstitution during antiretroviral therapy. We explore the baseline CD4/CD8 ratio in healthy individuals, scrutinize its prognostic significance in HIV progression, and assess its dynamic changes throughout treatment. Additionally, the article addresses challenges, controversies, and future directions in CD4/CD8 ratio research, offering a comprehensive overview of its potential as a key immunological marker in the ongoing battle against HIV.