Abstract

This study was carried out to evaluate levels of thyroid hormones in patients with congestive heart failure. A total of sixty (60) subjects aged forty-five (45) – sixty-five (65) years were recruited for the study and were divided into two groups subjects with congestive heart failure and control subjects. The data was analysed using SPSS version 21.0. The probability P < 0.05 was statistically significant. The serum thyroid stimulating hormones, triiodothyronine, thyroxine was assayed using ELISA method. The mean value of P< 0.05 was considered significant. The result obtained showed a significant higher (P = 0.0001) in thyroid stimulating hormone (6.65±0.57m/u/l). in subjects with congestive heart failure (subjects) when compared with thyroid stimulating hormone (2.91±0.23m/u/l) in control. There was significant lower (P=0.0001) in triiodothyronine (0.99±005ng/dl) in test when compared with triiodothyronine (2.25±0.288ng/dl) in control. There was significant lower (P= 0.01) in thyroxine (122.98±1734ng/dl) in test when compared with thyroxine (131.32±2.26ng/dl) in control. There was a non-significant positive correlation (r = 0.08, p = 0.682 and r = 0.16, p = 0.407) between thyroid stimulating hormone with triiodothyronine and thyroxine in congestive heart failure. It was however confirmed that patients with congestive heart failure have higher serum levels of thyroid stimulating hormone with relatively reduced triiodothyronine and thyroxine. The higher and lower level of thyroid hormone found in congestive heart failure should dysregulation in thyroid immune which can lead t0 complication and death. Therefore, it was concluded that thyroid hormones influence the cells and tissue of the heart and its homeostasis is essential to the optimal functioning of the heart, study support an association of thyroid dysfunction with increased risk for congestive heart failure.