Abstract

There is a continuous increase in the prevalence of renal disease worldwide as well as in Nigeria and the patient with severe renal failure are at risk of bleeding diathesis. This study was designed to investigate the status of some haemostatic and inflammatory parameters in patients with kidney disease and to compare their effect on different types of kidney disease. A total number of 104 participants (52 with kidney disease and 52 without kidney disease) were recruited. Data on socio-demographic was collected using questionnaire while laboratory result was generated using appropriate laboratory methods. The result obtained showed PT and APTT was significantly higher in renal disease subject compared to the control subjects (39.42±33.68 and 13.46±1.24 seconds) and (72.34±35.52and 43.42±9.36 seconds) respectively. There was no significant difference in Platelet count of renal disease patient and the control subject. There was a significant increase in the ESR and TLC of the subjects compared with the control. There was no significance difference in PT, APTT, platelet count, ESR and TLC between male and female subject. There was no significance difference in PT, activated partial thromboplastin time APTT, platelet count, ESR and TLC in age of renal disease subjects. P-value of <0.05 was considered significant in all the analysis. There is need to routinely monitor the haemostatic parameters among patient with renal diseases. In conclusion, this study has shown that kidney failure leads to increased level of Prothrombin Time, Partial Thromboplastin Time with Kaolin