Abstract

This review examines the intricate interplay between blood transfusion and antiretroviral medications, shedding light on the implications for patient care in individuals living with HIV. The coexistence of these two critical interventions introduces complexities that extend beyond routine considerations in both transfusion medicine and HIV management. Potential interactions between transfused blood components and antiretroviral drugs can impact drug efficacy, absorption, and metabolism, influencing treatment outcomes and posing challenges to healthcare providers. Immune system modulation, a phenomenon associated with blood transfusions, is explored in the context of its influence on the immunological effects of antiretroviral medications. Considerations extend to the pediatric population, where unique challenges arise concerning developmental aspects of drug metabolism and transfusion effects. Therapeutic drug monitoring (TDM) emerges as a valuable tool in managing the complex interactions between blood transfusion and antiretroviral medications. Regular monitoring of drug levels in the bloodstream allows for personalized adjustments to medication regimens, ensuring optimal therapeutic efficacy while minimizing the risk of toxicity. In conclusion, this review provides a comprehensive analysis of the interactions between blood transfusion and antiretroviral medications, offering insights into the challenges faced by healthcare providers and the considerations necessary for optimizing patient care. By enhancing our understanding of these interactions, healthcare professionals can tailor interventions, monitor treatment responses effectively, and provide individualized care for individuals living with HIV requiring blood transfusions