Abstract

Immune dysregulation is a hallmark feature of HIV/AIDS, contributing significantly to disease progression and complications. Despite advancements in antiretroviral therapy (ART), immune dysfunction persists in HIV/AIDS patients, necessitating a deeper understanding of its underlying molecular mechanisms and the identification of novel therapeutic targets. GATA-1, a critical transcription factor primarily recognized for its role in erythropoiesis, has emerged as a key regulator of immune function. This review explores the intricate interplay between GATA-1 and immune dysregulation in HIV/AIDS, encompassing molecular mechanisms, clinical implications, and potential therapeutic interventions. Insights into the multifaceted role of GATA-1 in immune cell development, cytokine regulation, and inflammatory responses provide novel perspectives on HIV pathogenesis and therapeutic targeting. Understanding the molecular mechanisms underlying GATA-1-mediated immune dysregulation may pave the way for innovative therapeutic strategies aimed at modulating immune function and improving outcomes in HIV/AIDS.