Abstract

GATA-1, a key transcription factor, plays a crucial role in regulating megakaryocyte function and platelet production. In the context of HIV infection, dysregulation of GATA-1 signaling pathways contributes to hematologic abnormalities, including thrombocytopenia and impaired platelet function. This review provides a comprehensive overview of the role of GATA-1 in megakaryocyte biology and platelet production, with a specific focus on its implications during HIV infection. We discuss the molecular mechanisms underlying GATA-1-mediated regulation of megakaryopoiesis, highlighting its role in lineage commitment, proliferation, and differentiation of megakaryocyte progenitors. Furthermore, we examine the impact of HIV infection on GATA-1 expression and activity, exploring how viral factors and immune dysregulation contribute to aberrant megakaryocyte function and platelet production. Understanding the role of GATA-1 in the context of HIV-related hematologic complications provides insights into potential therapeutic targets and strategies to mitigate thrombocytopenia and associated comorbidities in HIV-infected individuals