Abstract

Herbal medicines, including Kabuuti cough syrup, have gained popularity in treating various ailments, yet
their safety and efficacy require scientific scrutiny. This study aimed to evaluate the hematological and
biochemical effects of Kabuuti herbal cough syrup after 28 days of oral administration in Wistar rats. The
herbal extracts, containing secondary metabolites like terpenes, alkaloids, steroids, and phenols, were
administered at different doses to rats, with distilled water as a control. Hematological and biochemical
parameters were assessed, showing no statistically significant changes in most parameters. However, there
were decreases in mean corpuscular volume (MCV) levels and lymphocyte percentage, and increases in
hemoglobin (HB) levels and gamma glutamyl transferase (GGT) levels observed in certain dosage groups.
Despite these variations, the overall findings suggest that Kabuuti herbal cough syrup is safe for liver and
kidney function in the short term, with no significant adverse effects observed.
Keywords: Kabuuti Cough Herbal