Abstract

Depression and anxiety are prevalent co-morbidities among individuals with chronic alcohol consumption,
posing significant health challenges worldwide. This study aimed to explore the potential protective effects
of a tryptophan-based diet against depressive tendencies and anxiety associated with chronic alcohol
consumption. Using an experimental design, Wistar rats were subjected to chronic alcohol administration
along with varying doses of a tryptophan-based diet over 28 days. Behavioral tests including the Elevated
Plus Maze (EPM) and Forced Swim Test (FST) were conducted to evaluate anxiety-like behavior and
depressive tendencies, respectively. Results indicated a significant decrease in immobility time in the FST
with increasing doses of the tryptophan-based diet, suggesting antidepressant effects. Moreover, the anxiety
index decreased while the time spent on open arms increased with higher doses of the diet in the EPM,
indicating anxiolytic effects. These findings suggest that a high tryptophan-based diet could serve as a
potential intervention for individuals with alcohol-related depression and anxiety