Abstract

T-cell dysfunction is a hallmark feature of HIV infection, contributing to disease progression and susceptibility to opportunistic infections. GATA-1, a key transcription factor traditionally associated with erythropoiesis, has emerged as a critical regulator of T-cell development and function. This review explores the intricate relationship between GATA-1 and T-cell development in the setting of HIV infection. Insights into the molecular mechanisms underlying GATA-1-mediated immune dysregulation provide novel perspectives on HIV pathogenesis and therapeutic targeting. Understanding the role of GATA-1 in T-cell development may offer opportunities for developing targeted interventions to mitigate immune dysfunction and improve outcomes in HIV-infected individuals