Abstract

Hematological disorders are common complications of HIV infection, characterized by immune dysregulation, chronic inflammation, and aberrant hematopoiesis. GATA-1, a critical transcription factor in hematopoiesis, has emerged as a key regulator of inflammatory signaling pathways in the context of HIV-related hematological disorders. This review examines the multifaceted role of GATA-1 in modulating inflammatory signaling pathways and hematopoietic function during HIV infection, highlighting its implications for disease pathogenesis and therapeutic interventions. Insights into the interplay between GATA-1 and inflammatory signaling pathways offer potential targets for mitigating immune dysregulation and improving hematological outcomes in HIV-infected individuals.