Abstract

Hematological complications, including thrombosis and bleeding disorders, are significant contributors to morbidity and mortality in individuals living with Human Immunodeficiency Virus (HIV) infection. Dysregulation of the coagulation cascade plays a pivotal role in the pathogenesis of these complications. GATA-1, a master transcription factor in hematopoiesis, has emerged as a key regulator of coagulation cascade components and endothelial function. This review explores the multifaceted role of GATA-1 in modulating the coagulation cascade and endothelial function in the context of HIV-associated hematological complications. Insights into the interplay between GATA-1 and the coagulation cascade offer potential targets for therapeutic intervention and may lead to improved management of hematological complications in HIV-infected individuals.