Abstract

Eosinophilic infiltration in gestational tissues of HIV-infected pregnant women is a phenomenon of growing interest
due to its potential implications for maternal-fetal health. This paper explores the current understanding of
eosinophilic infiltration in the context of HIV infection during pregnancy, focusing on its prevalence, clinical
significance, and underlying mechanisms. Eosinophils, known for their roles in immune modulation and tissue
homeostasis, have been implicated in various pregnancy complications and inflammatory disorders. In HIV-infected
pregnancies, aberrant eosinophilic responses may contribute to adverse gestational outcomes and vertical transmission
of HIV. Despite limited characterization, emerging evidence suggests a potential link between eosinophilic infiltration
and placental dysfunction, fetal growth restriction, and preterm birth in this population. Understanding the complex
interplay between eosinophils, HIV infection, and pregnancy is crucial for elucidating the underlying pathophysiology
and developing targeted interventions to improve maternal and fetal health outcomes. Further research is needed to
unravel the mechanistic links between eosinophilic infiltration and adverse gestational outcomes in HIV-infected
pregnant women, paving the way for more effective strategies to mitigate risks and enhance maternal-fetal health in
this vulnerable population