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Relationship Levels of Proteinuria and Adverse Perinatal Outcomes among Pre-Eclamptic Mothers Delivering at Fort Portal and Mubende Regional Referral Hospitals, Uganda

Author: Muktar Abdi Yusuf, Hakizimana Theoneste, Fernando Perez Ramirez, Dayyabu Shehu, Abdinasir Abdi Ibrahim, Okurut Emmanual and Carlos Baptista
Publisher: EURASIAN EXPERIMENT JOURNAL OF BIOLOGICAL SCIENCES
Published: 2024
Section: Faculty of Clinical Medicine and Dentistry

Abstract

Pre-eclampsia, a complex pregnancy disorder, poses significant risks to maternal and fetal well-being. Proteinuria
levels, and adverse perinatal outcomes among women with pre-eclamptic patients. A prospective cohort study
involving 288 pre-eclamptic women, those done we meticulously collected socio-demographic and obstetric data.
Proteinuria levels were categorized (mild, moderate, severe, or massive), while adverse perinatal outcomes (low
Apgar score at 5th minute, low birth weight, NICU admission, stillbirth, perinatal death) were assessed. Logistic
regression determined associations, with significance set at p < 0.05. 51.74% faced adverse perinatal outcomes. those
with mild proteinuria were 5.25 times more likely to experience adverse outcomes, 51.74 had adverse perinatal
outcomes massive perineuria had 22.50 chance of getting adverse perinatal outcome, severe perineuria had 15.55
times more likely to get adverse perinatal outcomes and massive perineuria waste adverse perinatal outcomes (p <
0.001). This study underscores the pivotal role of proteinuria levels in shaping adverse perinatal outcomes in preeclamptic
women. The link between the severity of pre-eclampsia and ANC attendance with adverse outcomes
highlights the multifaceted nature of maternal and fetal health in this population. Tailored interventions, intensified
ANC, and robust risk stratification are imperative for enhancing the well-being of both mothers and newborns.
Keywords: Pre-eclampsia, Proteinuria, Adverse Perinatal Outcomes, Antenatal Care (ANC), Logistic Regression
Analysis