Abstract

Transfusion-related complications pose significant challenges in the management of children with severe malaria, HIV infection, and underlying hematological disorders. This comprehensive review examines the epidemiology, pathophysiology, clinical manifestations, and management strategies for transfusion-related complications in pediatric patients with these conditions. We explore the interplay between severe malaria, HIV, and underlying hematological disorders, highlighting the complexities encountered in clinical practice. Additionally, we discuss strategies for mitigating transfusion-related risks and optimizing patient outcomes. By synthesizing current evidence and clinical insights, this review provides a comprehensive understanding of transfusion-related complications in children with severe malaria, HIV, and underlying hematological disorders, aiming to inform and guide healthcare providers in their management of this vulnerable population.