Abstract

Blood transfusion is a critical intervention in the management of severe malaria in pediatric patients, particularly in those with concurrent HIV infection. While transfusion therapy aims to improve hemoglobin levels and tissue perfusion, its impact on the quality of life (QoL) of HIV-positive children recovering from severe malaria remains underexplored. This review examines the multifaceted impact of blood transfusion on the QoL of HIV-positive children recovering from severe malaria. We discuss the physiological and psychosocial factors influencing QoL in this population, including transfusion-related complications, disease burden, and social support networks. Additionally, we explore strategies for optimizing transfusion therapy to minimize adverse effects and enhance QoL outcomes. By synthesizing existing evidence and clinical insights, this review aims to elucidate the complex interplay between blood transfusion and QoL in HIV-positive children recovering from severe malaria, informing clinical practice and guiding future research efforts.