Abstract

Transfusion therapy plays a critical role in managing severe malaria-related complications, particularly in pediatric populations. However, in the context of HIV coinfection, transfusion-related complications may exacerbate neurological vulnerabilities in affected children. This review provides a comprehensive examination of transfusion-related complications in pediatric severe malaria cases, with a specific focus on the implications of HIV coinfection. We explore the multifaceted interplay between severe malaria, HIV, and transfusion therapy, highlighting the neurocognitive effects and clinical management strategies associated with these complications. By elucidating the complex dynamics of transfusion-related complications in pediatric severe malaria cases, this review aims to inform clinical practice and guide future research directions.