Abstract

Blood transfusion is a life-saving intervention often employed in the management of severe malaria-related complications, particularly in pediatric populations. However, in regions with high HIV prevalence, the co-occurrence of HIV infection complicates transfusion therapy and raises concerns regarding safety and tolerance. This review examines the safety and tolerance of blood transfusion in severe malaria cases with HIV, focusing on lessons learned from pediatric cases. The paper explores the epidemiology of severe malaria and HIV co-infection in children, discuss the indications and risks associated with blood transfusion, and review strategies for mitigating transfusion-related complications. By synthesizing available evidence and clinical experience, this review aims to provide insights into optimizing transfusion therapy and improving outcomes for pediatric patients with severe malaria and HIV co-infection