Abstract

Severe malaria and HIV co-infection pose significant challenges in pediatric healthcare, particularly in regions where both diseases are endemic. Thrombocytopenia is a common complication of severe malaria, necessitating blood transfusion to prevent hemorrhagic complications. However, the impact of blood transfusion on thrombopoiesis in pediatric severe malaria cases with HIV co-infection remains poorly understood. This review examines the current literature on transfusion-related alterations in thrombopoiesis in pediatric severe malaria cases with HIV, focusing on the pathophysiological mechanisms, clinical implications, and future research directions. By synthesizing existing evidence and clinical insights, this review aims to enhance our understanding of the complex interplay between transfusion, thrombopoiesis, and disease pathogenesis in this vulnerable population