Abstract

Tuberculosis (TB) and Human Immunodeficiency Virus (HIV) coinfection pose significant challenges to global health, with intricate interactions between these pathogens influencing immune responses and disease outcomes. L-selectin, a cell adhesion molecule crucial for leukocyte trafficking and immune surveillance, has emerged as a key player in the pathogenesis of TB-HIV coinfection. This review explores the role of L-selectin in TB-HIV coinfection, focusing on its implications for immune activation and dysfunction. We discuss the modulation of L-selectin expression and function by TB and HIV, as well as its impact on immune responses, disease progression, and therapeutic strategies. Understanding the role of L-selectin in TB-HIV coinfection provides insights into disease pathogenesis and highlights opportunities for targeted interventions to improve patient outcomes.