Abstract

Tuberculosis (TB) and human immunodeficiency virus (HIV) coinfection presents a complex challenge in global health, characterized by heightened disease severity and therapeutic complexities. Immune dysregulation plays a pivotal role in the pathogenesis of TB-HIV coinfection, influencing disease progression and clinical outcomes. L-selectin, a key adhesion molecule involved in immune cell trafficking, has emerged as a critical mediator in this interaction. Modulation of L-selectin expression impacts immune cell recruitment, homing, and activation, thereby influencing host immune responses to both TB and HIV. This review explores the modulation of L-selectin expression in TB-HIV coinfection and its implications for disease control. We discuss the mechanisms underlying L-selectin regulation, its role in immune cell trafficking, and the potential therapeutic strategies targeting L-selectin for disease management. Understanding the intricate interplay between L-selectin and TB-HIV coinfection offers promising avenues for the development of novel immunotherapeutic interventions and the optimization of disease control strategies