Abstract

This study was aimed at evaluating the association of acute phase protein with diurnal variation of blood pressure
among healthy pre and post-menopausal women. The study population consisted of 40 postmenopausal women and
premenopausal women (Control). Blood samples collected were used in the assay of acute phase proteins. C-reactive
protein, fibrinogen, ferritin and haptoglobin was determined using standard laboratory procedures. All data obtained
in the study were analyzed using student t-test (spss.21). The level of significance was set at p < 0.05. The mean
value of systole was significantly increased (p=0.001) in Nornotensive menopausal women (126.30±6.63) mmHg
when compared to normotensive premenopausal women (116.60±4.33) mmHg. The mean value of diastole was
significantly increased (p=0.000) in normotensive menopausal women (77.20±5.51) mmHg when compared to
normotensive premenopausal women (68.40±3.37) mmHg. The mean value of C-reactive protein was significantly
increased (p=0.002) in normotensive menopausal women (3.04±0.74)ng/ml when compared to normotensive
premenopausal women (1.99±0.55)ng/ml. The mean value of haptoglobin was significantly increased (p=0.037) in
normotensive menopausal women (2.08±1.15)g/L when compared to normotensive premenopausal women
(1.24±0.26)g/L. There was no significant difference (p=0.525) in the mean value of fibrinogen in normotensive
menopausal women (3.53±0.87)nmol/L when compared to normotensive premenopausal women
(3.81±1.02)nmol/L. There was no significant difference (p=0.299) in the mean value of ferritin in normotensive
menopausal women (2.95±0.59)ng/L when compared to normotensive premenopausal women (2.69±0.48)ng/L.
The mean value of C-reactive protein was significantly increased (p=0.000) in hypertensive menopausal women
(4.31±0.85)ng/ml when compared to normotensive premenopausal women (1.99±0.55)ng/ml. The mean value of
fibrinogen was significantly increased (p=0.038) in hypertensive menopausal women (4.89±1.13)nmol/L when
compared to normotensive premenopausal women (3.81±1.02)g/L. The mean value of haptoglobin was significantly
increased (p=0.000) in hypertensive menopausal women (2.95±1.24)gl/L when compared to normotensive
premenopausal women (1.24±0.26)g/L. The mean value of ferritin was significantly increased (p=0.021) in
hypertensive menopausal women (3.30±0.59)ng/L when compared to normotensive premenopausal women
(2.69±0.48)ng/L. The mean value of C-reactive protein was significantly increased (p=0.002) in hypertensive
menopausal women (4.31±0.85)ng/ml when compared to normotensive menopausal women (3.04±0.74)ng/ml. The
mean value of fibrinogen was significantly increased (p=0.008) in hypertensive menopausal women
(4.89±1.13)nmol/L when compared to normotensive menopausal women (3.53±0.87)mmol/L. There was no significant difference (p=0.122) in the mean value of haptoglobin in hypertensive menopausal women
(2.95±1.24)gl/L when compared to normotensive menopausal women (2.08±1.15)g/L. There was no significant
difference (p=0.204) in the mean value of ferritin in hypertensive menopausal women (3.30±0.59)ngl/L when
compared to normotensive menopausal women (2.95±0.59)ng/L. From the study, Menopausal women with high
blood pressure presented with significant increase in C-reactive protein, fibrinogen, haptoglobin and ferritin.