Abstract

Platelets are anucleated disc-shaped blood stem cells which play significant roles in modulating bleeding. Platelets play key roles in inflammation, infection and host response. Platelets release and accumulate adhesion molecules at infection sites and trigger inflammatory reactions with the aid of these molecules. Platelets, or thrombocytes, are small, colorless cell fragments in our blood that form clots and stop or prevent bleeding. Platelets are made in our
bone marrow, the sponge-like tissue inside our bones. Platelets are highly reactive blood cells which play key roles in maintaining homeostasis. When activated, platelets have been seen to have a significant impact on the start and continuation of inflammatory responses. It is now known that active platelets regulate local inflammatory responses, such as touch sensitivity, inflammatory bowel disease, and atherosclerosis, by interacting with endothelial cells and
infiltrating leukocytes through platelet-derived immunomodulatory ligands.