Abstract

Aim: This study was aimed at determining the prevalence and factors of pre-diabetes (PD) among first degree relatives, (FDRs) of
type 2 diabetes, (T2D) subjects in Abakaliki Metropolis, Ebonyi State, Nigeria.
Methods: 100 participants (70 men and 30 women) were selected through respondent-driven sampling and interviewed about
their knowledge, common symptoms and family history of T2D. Venous blood samples were collected after an overnight fast and
2 hours after a 75g oral dose of 75g anhydrous glucose. Samples were collected into fluoride-oxalate bottles, kept at 40ºC and
analyzed within 1 hour of collection by the glucose oxidase method. Data were analyzed using SPSS 20.0 and summarized as
mean and standard deviation.
Results: Twenty-two FDRs – (17 male and 5 females) had PD giving prevalence rates of 22%, 24.3% and 16.7% respectively for
the entire study, males and females populations respectively. 13 (11 male, 2 females; 84.6% and 6.7%) of FDRs with PD had IFG
only while 3 each – (4.3 and 10% respectively) - had IGT only. 3 males only (4.3%) had both IFG and IGT. The BMI of subjects
with IGT (23.80 ± 2.68 kg/m2) was significantly higher than IFG (22.09 ± 1.94 kg/m2) (p = 0.028). Female subjects with PD had
significantly higher BMI (21.8 ± 3.38 vs 21.73 ± 3.15 kg/m2; p = 0.035) than the male FDRs. Almost 25% of FDRs of T2D subjects
in Abakaliki have PD and are at risk of developing diabetes.
Conclusion: More men than women were affected. Body mass, among others, may be a contributing factor.