Abstract

Wound healing is a complex biological process involving hemostasis, inflammation, proliferation, and remodeling. 
Medicinal plants, used since antiquity, remain a primary therapeutic option in many cultures due to their 
accessibility, affordability, and diverse pharmacological activities. Evidence shows that bioactive compounds such 
as flavonoids, tannins, alkaloids, saponins, and terpenes accelerate wound closure, reduce infection, and promote 
tissue regeneration through antioxidant, anti-inflammatory, antimicrobial, and angiogenic mechanisms. Common 
plants such as Aloe vera, Calendula officinalis, honey, tea tree oil, and lavender have demonstrated significant 
wound-healing potential in experimental and clinical settings. Despite promising outcomes, challenges remain 
regarding safety, standardization, dosage, and drug interactions. This review highlights the historical background, 
mechanisms of action, phytochemical contributions, and clinical evidence supporting medicinal plants in wound 
management. It also underscores the need for further research, ethical considerations, and innovative formulations 
to integrate traditional knowledge with modern pharmacological approaches for safe and effective wound care.