Abstract

Malaria remains one of the most persistent global health challenges, with over 200 million cases annually 
and significant mortality, particularly in sub-Saharan Africa. Fever, a primary symptom of malaria, often 
compels individuals to seek medical care. Conventional antimalarial drugs face increasing resistance and 
can present severe side effects, making searching for alternative treatments both urgent and necessary. 
Medicinal plants have long been used in traditional medicine to treat malaria-related fever and offer an 
accessible, affordable, and culturally accepted solution, especially in developing nations. This paper 
explores the role of key medicinal plants such as Azadirachta indica (Neem), Ajuga remota, and Aloe 
macrocarpa in managing malaria fever. It reviews their phytochemical composition, pharmacological 
efficacy, safety concerns, and the outcomes of related clinical studies. Furthermore, it considers the 
cultural dimensions that shape the use of traditional medicine in malaria-endemic areas. While promising, 
the widespread adoption of plant-based antimalarial therapies requires rigorous scientific validation to 
ensure their safety, efficacy, and integration into modern healthcare systems.