Abstract

Obesity is a growing global epidemic, associated with diabetes, cardiovascular disease, cancer, and diminished 
life expectancy. Pharmacological treatments are often limited by poor bioavailability, low target specificity, and 
systemic toxicity. Nanotechnology offers innovative drug delivery solutions, improving solubility, stability, 
biodistribution, and therapeutic precision. Nanocarriers including liposomes, polymeric nanoparticles, 
dendrimers, micelles, and lipid-based systems have demonstrated potential for encapsulating anti-obesity drugs, 
nutraceuticals, and genetic material. These advances can enhance efficacy while minimizing adverse effects. This 
review explores the role of nanotechnology in obesity management, focusing on principles of design, recent 
advances, clinical translation, challenges, and future perspectives. Nanomedicine holds promise to revolutionize 
obesity therapy, though safety, manufacturing, and regulatory hurdles must be addressed. 
Keywords: Obesity, Nanotechnology, Drug delivery, Nanocarriers, Therapeutics