Abstract

Background: Tis study investigated the efect of the extractable hypoglycaemic principles from Securidaca longepe
dunculata leaves on some biochemical parameters in alloxan-induced diabetic rats with the view to having improved
pharmacological agent(s) that could be used in managing diabetes mellitus with relatively lesser side efects. Tree groups
of four rats each were used for the oral glucose tolerance test (OGTT): group one received 3mL/kg BW normal saline
(normal control) while groups 2 and 3 received 200 and 400mg/kg BW of methanol extract of Securidaca longepe
dunculata (MESL), respectively. Six groups of fve rats per group were used for the main antidiabetic study. Group one
received 3mL/kg BW normal saline (normal control), group 2 received no treatment after induction, group 3, received
5mg/kg BWglibenclamide (standard group), groups 3–6 received 100, 200, and 400mg/kg BW MESL, respectively, after
induction.
Results: Te OGTTshowedsignifcant (p<0.05) reduction in random blood sugar of the treated groups compared to the control.
In the antidiabetic study, the treated groups 4–6 signifcantly (p<0.05) lowered the blood glucose of the Wistar rats compared to
the treatment control. Extract administration showed no adversity to liver and kidney, respectively, as shown by result of tested
standard indicators. Equally MESL caused signifcant (p<0.05) increase in serum antioxidant activities and signifcant (p<0.05)
decrease in malondialdehyde concentration compared to the treatment control.
Conclusion: Te study suggested hypoglycaemic potency, antioxidant rejuvenation, and relative hepatic and nephron safety
by MESL.