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Impact of antibiotics on the genomic expression of Pseudomonas aeruginosa in the East African community: a systematic review
Author: Comfort Danchal Vandu, Ilemobayo Victor Fasogbon, Angela Mumbua Musyoka, Abdulganiy Babatunde Agbaje, Anyanwu Chinyere Njideka, Wusa Makena, Emmanuel O. Ikuomola, Reuben Samson Dangana, Nancy B. Mitaki, Ibe Micheal Usman, Augustine Oviosun, Herbert Mbyemeire, Elizabeth Umoren, Shango Patience Emmanuel Jakheng, Solomon A Mbina, Esther Ugo Alum, Ibrahim Babangida Abubarkar, Swase Dominic Terkimbi, Siida Robert, Patrick Maduabuchi Aja, Ezra Agwu
Publisher: F1000 Research
Published: 2025
Section: Faculty of Biomedical Sciences
Abstract
Objectives
This systematic review aimed to assess the impact of antibiotics on
gene expression in Pseudomonas spp. within the East African
Community (EAC).
Methodology
A thorough literature search across Web of Science, Scopus, and
PubMed yielded 284 articles, of which 11 met the inclusion criteria
after screening. The selected studies came from five EAC countries.
Findings showed a high prevalence of AMR in Pseudomonas aeruginosa
, with over 90% resistance to most antibiotics, except Amikacin, which
remained effective likely due to limited usage.
Results and discussion
Common resistance genes identified included carbapenemases such
as blaNDM-1 and blaVIM. The disc diffusion method was the most
commonly used technique (50%).Multidrug-resistant clones like ST244
and ST357 were frequently reported. Environmental isolates had
lower resistance rates (54%) compared to clinical strains (73%),
suggesting differing selection pressures. Most studies originated from
Kenya and Uganda (each 30%), reflecting differences in research
capacity and healthcare infrastructure across the region.
Conclusion
These results underscore the urgent need for expanded AMR
surveillance, stronger antimicrobial stewardship, and further research
to inform public health responses in East Africa