Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is spreading around the world, with prevalence ranging from 23.3
% to 73 %. This study, therefore, evaluated the antibacterial activity of a combination of crude juice extracts of Allium
sativum and Curcuma longa against methicillin-resistant Staphylococcus aureus. The combined crude juice extracts
exhibited moderate antibacterial activity against methicillin-resistant Staphylococcus aureus, which was determined
by the agar well diffusion method where the Allium sativum crude juice extract revealed a high level of antibacterial
activity with the highest mean and standard error of the mean inhibition zone diameters of 21.67 ± 0.88 mm at
concentration 100%v/v compared at a concentration of 50%v/v which showed a mean and standard error of the
mean inhibition zone diameter of 21.33 ± 0.67 mm. On the other hand, Curcuma longa crude juice extract didn’t show
any antibacterial activity against the test organism. The minimum inhibitory concentration (MIC) of the
combination of the crude juice extracts of Allium sativum and Curcuma longa crude juice extracts was 25%v/v, Allium
sativum was 25%v/v w and Curcuma longa was 0%v/v. The minimum bactericidal concentration (MBC) results that
the study extract was bacteriostatic since all used concentrations showed visible growth after overnight incubation.
The FIC of the extract was 1 hence there was an additive antibacterial effect of the extract combination.