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The demonstration of expressed microsatelite proteins (MSH2) on colorectal carcinoma tissue
Author: Chukwunalu Igbudu Umoke; Kenneth Tochukwu Onwe; Paul Orieji; Chukwudum Collins Umoke; Emmanuel Ifeanyi Obeagu
Publisher: NEWPORT INTERNATIONAL JOURNAL OF RESEARCH IN MEDICAL SCIENCES
Published: 2023
Section: School of Allied Health Sciences
Abstract
This study was carried out to evaluate the expression of microsatellite protein (MSH2) on colorectal cancer
specimen. A total of 32 tissue specimens of colorectal carcinoma from Meena Histopathological and Pap
smear Screening Centre Jos and Federal staff Hospital Abuja were reviewed and analyzed
Immunohistochemcially for the expression of MSH2 protein with colorectal cancer samples. Nineteen
(59.3%) of colorectal cancer revealed 17(53.1%) showed negative reaction to MSH2 protein. Five (35.7%) of
moderate differentiated adenocarcinoma showed stage II of colorectal cancer with MSH2 protein and
1(7.1%) showed stage III of colorectal cancer with MSH2 protein. Four (40%) of well differentiated
adenocarcinoma revealed stage II of colorectal cancer while 2(20%) showed stage III of colorectal cancer
with MSH2 protein. In one (12.5%) of poor differentiated adenocarcinoma were stage II of colorectal cancer
with MSH2 protein and 2(25%) showed stage III of colorectal cancer with MSH2 protein.