Abstract

One of the major causes of morbidity and mortality among newborns worldwide is neonatal sepsis. Limited
knowledge of the risk factors for newborn sepsis was accessible in Africa and other underdeveloped nations.
Among newborns hospitalized to the neonatal ICU of Lira Regional Referral Hospital, the study's goals were to
ascertain the prevalence of neonatal sepsis and related obstetric and neonatal risk factors. Data were collected
through a retrospective descriptive research, totaled, and then expressed as frequencies and percentages. Tables
and graphs were used to present the data. According to the study, out of the 690 newborns referred to the NICU
at Lira Regional Referral Hospital for neonatal intensive care, 242 (or 35.1%) had neonatal sepsis. Limited
knowledge of the risk factors for newborn sepsis was accessible in Africa and other underdeveloped nations.
Among newborns hospitalized to the neonatal ICU of Lira Regional Referral Hospital, the study's goals were to
ascertain the prevalence of neonatal sepsis and related obstetric and neonatal risk factors. Data were collected
through a retrospective descriptive research, totaled, and then expressed as frequencies and percentages. Tables
and graphs were used to present the data. According to the study, out of the 690 newborns referred to the NICU
at Lira Regional Referral Hospital for neonatal intensive care, 242 (or 35.1%) had neonatal sepsis. 60.3% (146)
of the newborns with sepsis were boys. 39.7% of the 96 females had EONS, whereas 180 of them had 76.9% and
62 of them (23.1%) had LONS. With 200 (82.7%), PROM was the major obstetric risk that contributed to
neonatal sepsis, while 142 out of 150 neonates whose mothers with a history of UTI experienced EONS at a rate
of 94.7%. Ninety-nine percent of newborns whose mothers skipped ANC developed LONS. Prematurity 180
(74.4%) was the main newborn risk factor for developing EONS and the biggest neonatal factor causing neonatal
sepsis. 77.4% of term infants have LONS. The majority of newborns who experienced EONS had mothers who
had both urinary tract infections and alcohol with a bad odor. The majority of neonates with LONS were born
to women who skipped prenatal care. The majority of newborns with gestational ages under 37 weeks. People
with EONS with an APGAR score of fewer than 7 weeks or a birth weight greater than 2.5 pounds suffered from
LONS. Urinary tract infections should be identified early and treated quickly. Encourage hospital deliveries and
prenatal care. Preventive measures like giving pregnant women insider and insecticide-treated mosquito nets,
routine blood pressure checks in women with pre-eclampsia, prompt treatment of maternal genital infections,
cervical cerclage for mothers with incompetent cervixes, and tocolysis when indicated should be put in place to
prevent premature delivery